Atrial natriuretic peptide inhibited the natriferic and hydrosmotic effects of arginine vasotocin on toad skin.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
; 109(3): 277-82, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7894890
ABSTRACT
The effect of rat atrial natriuretic peptide (rANP) on hormonal stimulated osmotic water permeability (Jw, hydrosmotic effect) and net ion transport (short-circuit current, SCC, natriferic effect) was studied on toad skin, a tissue with functional similarities to the mammalian distal nephron, in order to assess actions on transport mechanisms. Rat atrial natriuretic peptide, rANP-99-126 (rANP) inhibited stimulated SCC and Jw to submaximal concentrations of arginine vasotocin (AVT) at a site before cyclic AMP generation. The angiotensin-converting enzyme inhibitor (ACEI) MK-422 did not modify the inhibitory effect of ANP in the stimulated Jw.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Vasotocina
/
Fator Natriurético Atrial
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article