Suppression of peptide YY-induced hyperphagia by terbutaline.
Pharmacol Biochem Behav
; 46(3): 679-81, 1993 Nov.
Article
em En
| MEDLINE
| ID: mdl-7904074
ABSTRACT
Central administrations of neuropeptide Y and peptide YY (PYY) produce robust increases in food intake, and this response may be contingent upon the availability of insulin. In contrast, beta 2-adrenergic agonists decrease food intake, and this effect also appears to be dependent on circulating insulin. To investigate a possible interaction between PYY and beta 2-adrenergic function, rats were given systemic injections of terbutaline, a beta 2 agonist, at doses of 0, 5, 10, and 50 mg/kg prior to injections of 0.57 nmol PYY in the paraventricular nucleus of the hypothalamus. Terbutaline pretreatment significantly decreased feeding elicited by PYY in a dose-dependent fashion. This suggests that beta 2-adrenoreceptor activity is involved in PYY-induced feeding.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Terbutalina
/
Hiperfagia
/
Hormônios Gastrointestinais
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article