Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.
Cell
; 79(1): 49-58, 1994 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-7923376
ABSTRACT
Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Genes de Insetos
/
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
/
Drosophila
/
Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article