Characterization of zymosan-induced arthritis in the rat: effects on joint inflammation and cartilage metabolism.
Life Sci
; 55(17): PL321-6, 1994.
Article
em En
| MEDLINE
| ID: mdl-7934634
ABSTRACT
A single intra-articular (ia) injection of 2 mg zymosan on D0 led to the production of acute periarticular edema followed by subacute erosive synovitis. The development of the zymosan-induced arthritis was associated with an initial loss of running activity and with an initial decrease of proteoglycan synthesis. Febrile response was present only on D1. In addition, on D20 synovial pannus led to a marked depletion of the proteoglycan content in the articular cartilage. When injected ia, IL1 beta (1 microgram) provoked similar fever and similar changes in cartilage anabolism, but did not affect cartilage proteoglycan content (D20). These results suggest that zymosan-induced synovitis in the rat combines early prostaglandin-dependent processes (edema, pain, fever) with IL1-related effects on cartilage metabolism, thus allowing evaluation of chondroprotective drugs.
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Base de dados:
MEDLINE
Assunto principal:
Artrite
/
Zimosan
/
Cartilagem
/
Articulações
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article