On-demand antiemetic treatment with the serotonine antagonist tropisetron in cisplatin-treated cancer patients.
Anticancer Drugs
; 5(4): 410-8, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7949244
ABSTRACT
Fourteen cancer patients treated with cisplatin received repeated infusions of tropisetron on-demand in conjunction with emesis. In subsequent chemotherapy courses, prophylactic tropisetron was given in a dose identical to the cumulated dose in study course 1. Tropisetron in study course 1 abolished emesis after 7.5 min (5 mg). Duration of effect was more than 7 h in 50% of the patients. No relationship between dose and duration of effect was seen. After study course 2, eight of 10 patients preferred prophylactic tropisetron. Two patients with hypertension had a severe increase in blood pressure probably related to tropisetron. It is concluded that tropisetron has an instant and lasting effect on nausea and vomiting when given on-demand. The majority of patients, however, prefer prophylactic treatment. Hypertension may be a side effect from tropisetron and caution should be displayed in hypertensive patients.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Antagonistas da Serotonina
/
Vômito
/
Cisplatino
/
Neoplasias de Cabeça e Pescoço
/
Indóis
/
Antieméticos
/
Náusea
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article