Comparative profile of tizanidine in the management of spasticity.
Neurology
; 44(11 Suppl 9): S53-9, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7970011
ABSTRACT
The therapeutic profile of a new antispastic drug cannot be defined solely on the basis of placebo-controlled studies. Its potential advantages must be evaluated in comparison with existing drugs. This review compares the efficacy and tolerability of tizanidine, a newer muscle relaxant, with that of baclofen and diazepam, the most widely used antispastic agents, for a variety of diagnoses and target symptoms associated with spasticity. More than 20 double-blind, comparative studies were conducted between 1977 and 1987. These included a total of 777 patients suffering from spasticity of various causes. The collected clinical data have been integrated into a combined analysis. Tizanidine emerges from this comparison as a valuable drug in the treatment of spasticity related to cerebral and spinal disorders.
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Base de dados:
MEDLINE
Assunto principal:
Clonidina
/
Relaxantes Musculares Centrais
/
Espasticidade Muscular
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article