Modulation of fast excitatory synaptic transmission by cyclothiazide and GYKI 52466 in the rat hippocampus.
Neurosci Lett
; 175(1-2): 21-4, 1994 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-7970204
ABSTRACT
The effects of cyclothiazide, a drug which potentiates AMPA receptor-mediated responses and GYKI 52466, a non-competitive AMPA receptor antagonist, were studied on fast glutamatergic transmission in rat hippocampal slices. Cyclothiazide prolonged the decay of AMPA receptor-mediated EPSCs (AMPA-EPSCs) in a concentration-dependent manner. GYKI 52466 reduced the peak amplitude of AMPA-EPSCs and blocked the induction of LTP. When GYKI 52466 was applied in the presence of cyclothiazide it still reduced the peak amplitude of AMPA-EPSCs but was not able to reverse the cyclothiazide induced prolongation of AMPA-EPSC duration. These data suggest that GYKI 52466 and cyclothiazide probably mediate their effects on the AMPA receptor via different binding sites.
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Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Benzodiazepinas
/
Benzotiadiazinas
/
Potenciação de Longa Duração
/
Transmissão Sináptica
/
Antagonistas de Aminoácidos Excitatórios
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article