[18FDG-PET in intracranial meningiomas versus grading, proliferation index, cellular density and cytogenetic analysis]. / 18FDG-PET bei intrakraniellen Meningeomen versus Grading, Proliferationsindex, Zelldichte und zytogenetische Analyse.
Nuklearmedizin
; 33(4): 144-9, 1994 Aug.
Article
em De
| MEDLINE
| ID: mdl-7971289
ABSTRACT
62 intracranial meningiomas in 60 patients were studied with 18FDG-PET prior to neurosurgery in order to evaluate the relationship between 18FDG uptake and biological aggressiveness of the tumors. Histopathological grading, cellular density, Ki-67 proliferation index and evidence of chromosomal aberrations were used to assess tumor aggressiveness. Significantly elevated 18FDG uptake was found in grade 2- and 3- compared to grade 1-meningiomas, in tumors of high cellularity compared with those of low cellularity, and in meningiomas with an elevated Ki-67 proliferation index (above 2%). The two meningiomas with the most pronounced chromosomal aberrations revealed the highest 18FDG uptake of all cytogenetically studied meningiomas. We conclude that 18FDG-PET is useful for estimating the biological aggressiveness of intracranial meningiomas.
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Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Flúor
/
Tomografia Computadorizada de Emissão
/
Neoplasias Meníngeas
/
Meningioma
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Aged80
/
Animals
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
De
Ano de publicação:
1994
Tipo de documento:
Article