Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

Ding, W; Williams, D R; Northcote, P; Siegel, M M; Tsao, R; Ashcroft, J; Morton, G O; Alluri, M; Abbanat, D; Maiese, W M

Ding, W; Williams, D R; Northcote, P; Siegel, M M; Tsao, R; Ashcroft, J; Morton, G O; Alluri, M; Abbanat, D; Maiese, W M.

Afiliação

Ding W; Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.

J Antibiot (Tokyo) ; 47(11): 1250-7, 1994 Nov.

Article em En | MEDLINE | ID: mdl-8002387

ABSTRACT

ABSTRACT

Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.

Assuntos

Antibacterianos/isolamento & purificação; Macrolídeos; Streptomyces/metabolismo; Antibacterianos/química

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Base de dados: MEDLINE Assunto principal: Streptomyces / Macrolídeos / Antibacterianos Idioma: En Ano de publicação: 1994 Tipo de documento: Article

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PubMed Links

Base de dados: MEDLINE Assunto principal: Streptomyces / Macrolídeos / Antibacterianos Idioma: En Ano de publicação: 1994 Tipo de documento: Article