Mosaic and polymorphic imprinting of the WT1 gene in humans.
Nat Genet
; 6(3): 305-9, 1994 Mar.
Article
em En
| MEDLINE
| ID: mdl-8012395
We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 was also found in two fetal brains. These data demonstrate that WT1 can undergo tissue specific imprinting. Furthermore, because monoallelic expression of WT1 was not found in all placentae examined, WT1 imprinting may be genetically polymorphic within the human population.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Genes do Tumor de Wilms
/
Mosaicismo
Limite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article