Early and delayed brain SPECT with technetium-99m-ECD and iodine-123-IMP in subacute strokes.
J Nucl Med
; 35(9): 1444-9, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-8071689
ABSTRACT
UNLABELLED The brain distribution of 99mTc-ECD versus 123I-IMP was compared in patients with subacute stroke in order to compare diagnostic accuracy. METHODS:
A total of 25 patients with subacute stroke underwent early and delayed SPECT imaging with 99mTc-ECD and 123I-IMP. Washout of 99mTc-ECD was calculated and a differential percentage of activity (DPA) of ischemic versus normal zones was assessed. Images were analyzed twice by five independent observers.RESULTS:
Technetium-99m-ECD clearance was 12.5% from the whole brain during early imaging. Ischemic parietal zones had higher clearance than normal parietal zones. Technetium-99m-ECD images showed larger differences between abnormal and normal brain activity than 123I-IMP images. Detection accuracy was slightly, but not significantly, higher for 99mTc-ECD and 123I-IMP (sensitivity 73.8% as 66.6%; specificity 81.7% as 81.6%). Reproducibility among observers was similar for 99mTc-ECD and early 123I-IMP.CONCLUSION:
Technetium-99m-ECD demonstrates high diagnostic accuracy during subacute stroke, similar to 123I-IMP, but with more intense, better delineation of the perfusion defects.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Compostos de Organotecnécio
/
Transtornos Cerebrovasculares
/
Cisteína
/
Anfetaminas
/
Radioisótopos do Iodo
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article