[New directions in the hypotensive therapy of open-angle glaucoma (experimental and clinical research)]. / Novye napravleniia gipotenzivnoi terapii otkrytougol'noi glaukomy (éksperimental'no-klinicheskie issledovaniia).

ABSTRACT

Clinical use of eye drops of a hybrid beta-alpha-adrenoblocker OF-4680 to reduce intraocular pressure has shown a high efficacy of the drug, not inferior to thymolol, for local hypotensive therapy of open-angle glaucoma. A combination of thymolol with taurin helped reduce the inhibiting effect of the beta-blocker on chamber humor secretion and simultaneously enhanced its discharge. The results evidence the desirability of correcting glutathion deficiency, detected in the patients with narrow-angle glaucoma, by lipoic acid.