Increase of plasma adrenocorticotrophin and cortisol in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs.
Brain Res
; 612(1-2): 319-21, 1993 May 28.
Article
em En
| MEDLINE
| ID: mdl-8101134
ABSTRACT
Neuroendocrine abnormality of the hypothalamic-pituitary-adrenal axis was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs as a model of Parkinson's disease. Blood samples were collected every 4 h for 3-4 days before MPTP treatment, around 2 and 4 weeks after the treatment of MPTP (2.5 mg/kg). Adrenocorticotrophin (ACTH) and cortisol concentrations in plasma were determined by radioimmunoassay. The concentrations of plasma ACTH and cortisol increased by 40% and 60% after MPTP treatment, respectively. Circadian rhythms of neither plasma ACTH nor cortisol concentrations were observed in both MPTP-treated and control dogs. This high hypothalamic-pituitary-adrenal function in MPTP-treated dogs suggests that MPTP may influence the activity of the hypothalamic neurons of the dog.
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Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
/
Dopaminérgicos
/
1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina
/
Hormônio Adrenocorticotrópico
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article