Norplant-2 subdermal contraceptive system: experience in Taiwan.
J Formos Med Assoc
; 92(5): 446-50, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8104598
ABSTRACT
PIP: Between October 1986 and November 1988, physicians enrolled 267 20-41 year old women in a clinical trial of Norplant-2 (2 Silastic rods with 70 mg levonorgestrel each) at the National Taiwan University Hospital to evaluate the advantages and side effects of Norplant-2. 36 women were lost to follow up. 63% suffered from menstrual problems during the first 3 months. 73.6% of these women still had menstrual problems at 6 months. 6 women then chose to discontinue using Norplant-2. 51.8% of the remaining women had persistent menstrual problems at 1 year. 62% of women who discontinued Norplant-2 before the end of 3 years discontinued it due to menstrual problems. The continuation rate was 84.5% at 1 year, 61.3% at 2 years, and 52% at 3 years. 78.6% of women who discontinued Norplant-2 to become pregnant conceived within 1 year after its removal. Just 1 woman (.04%) became pregnant while using Norplant-2. She was thin and smoked heavily. Her aborted fetus had an abnormal fetus had an abnormal karyotype (47,XY,+22). The mean serum total cholesterol and triglyceride levels dropped considerably after Norplant-2 implantation from 164 to 147 mg/dl and from 81 to 63 mg/dl at 12 months, respectively; p .05). Mean hemoglobin levels increased from 12.6 g/dl to 13 g/dl at 12 months (p .05). Levonorgestrel did not affect liver or renal functions. Mean body weight and blood pressure remained the same. Observed psychophysiologic symptoms included depression, acne, headaches, nervousness, and insomnia. These findings indicated Norplant-2 to be safe, reversible, long-acting, and very effective, therefore the family planning program in Taiwan should add it to its contraceptive menu.
Palavras-chave
Asia; Biology; China; Cholesterol; Chromosome Abnormalities; Clinical Research; Clinical Trials; Contraception; Contraception Continuation; Contraception Failure; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Implants; Contraceptive Methods; Contraceptive Usage; Demographic Factors; Developing Countries; Diseases; Eastern Asia; Family Planning; Fertility; Fertility Measurements; Hemic System; Hemoglobin Level; Levonorgestrel--side effects; Lipid Metabolic Effects; Lipids; Menstruation Disorders; Neonatal Diseases And Abnormalities; Physiology; Population; Population Dynamics; Pregnancy Rate; Research Methodology; Reversibility; Taiwan
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Base de dados:
MEDLINE
Assunto principal:
Levanogestrel
/
Anticoncepção
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article