The influence of monophosphoryl lipid A (MPL) on erythrocyte autoantibody formation.
Immunobiology
; 189(5): 448-56, 1993 Dec.
Article
em En
| MEDLINE
| ID: mdl-8125521
ABSTRACT
The onset and the amount of erythrocyte autoantibodies induced by the injection of C57BL/6N mice with rat red blood cells (RRBC) were hastened and increased, respectively, after the administration of monophosphoryl lipid A (MPL); this was not the case for similarly treated BALB/cAnN mice, which make a lower autoantibody response after immunization with RRBC. The transfer of spleen cells from donor C57BL/6N mice immunized with RRBC suppressed autoantibody formation in recipient mice subsequently immunized with RRBC; however, treatment with MPL prevented neither the induction nor the expression of such suppression. This suggests that the increased autoantibody response in RRBC-immunized C57BL/6N mice treated with MPL is not due to the inactivation of suppressor cell activity which, in other studies, was found to be extremely sensitive to MPL.
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Eritrócitos
/
Lipídeo A
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article