Studies on mechanism of action of glycyrrhizin against hepatitis A virus replication in vitro.
Antiviral Res
; 23(1): 63-76, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-8141593
ABSTRACT
Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [3H]uridine-labelled virions to cells. GL inhibited HAV penetration of the plasma membrane as measured by the amount of infective virus no longer neutralizable by specific antibody over time.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Replicação Viral
/
Hepatovirus
/
Ácido Glicirretínico
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article