Transforming growth factor beta 1 preserves endothelial function after multiple brief coronary artery occlusions and reperfusion.
Am Heart J
; 127(6): 1456-61, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-8197968
ABSTRACT
The objective of this investigation was to determine the effect of transforming growth factor beta 1 (TGF-beta 1) on endothelium-dependent relaxation in isolated epicardial coronary artery rings obtained from anesthetized dogs after multiple brief episodes of coronary artery occlusion and reperfusion in vivo. Dogs were subjected to four 5-minute periods of left anterior descending coronary artery occlusion interspersed with 5 minutes of reperfusion and followed by a final 1-hour period of reperfusion. Normal left circumflex coronary arteries were used as control samples. Repetitive ischemia and reperfusion significantly (p < 0.01) inhibited the relaxation response to acetylcholine in rings preconstricted with potassium. In an additional group of dogs subjected to the same protocol, 10 micrograms of human recombinant TGF-beta 1 was infused into the left anterior descending coronary artery distal to the site of occlusion via a diagonal branch at 0.3 ml/min immediately before and during the repetitive occlusions and reperfusions. TGF-beta 1 prevented impaired endothelium-dependent relaxation after multiple brief occlusions and reperfusions. These results demonstrate a protective role for TGF-beta 1 in the endothelial injury that occurs during repeated episodes of coronary artery occlusion and reperfusion.
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Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Fator de Crescimento Transformador beta
/
Miocárdio Atordoado
/
Doença das Coronárias
/
Vasos Coronários
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article