Gas chromatography/combustion/isotope-ratio mass spectrometry analysis of urinary steroids to detect misuse of testosterone in sport.
Rapid Commun Mass Spectrom
; 8(4): 304-8, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8199357
ABSTRACT
We propose a new confirmatory method for testosterone doping in sport. The present method in use, based on measuring the testosterone/epitestosterone (T/E) ratio in urine, may miss suspicious cases, or lead to reporting cases in which the high ratio is natural. Synthetic testosterone has a 13C abundance different from that of endogenous human testosterone. The connection of a gas chromatograph to an isotope-ratio mass spectrometer via a combustion interface allows the measurement of the corresponding characteristic value (delta /1000) for testosterone, its precursors, and its metabolites. To detect exogenous administration of testosterone, 30-40 mL of urine is sufficient.
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Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Testosterona
/
Dopagem Esportivo
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article