Forward and reverse genetic approaches to behavior in the mouse.
Science
; 264(5166): 1724-33, 1994 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-8209253
ABSTRACT
Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. "Reverse genetics" (from gene to phenotype) with targeted gene transfer provides a powerful tool to dissect behavior and has been used successfully to study the effects of null mutations in genes implicated in the regulation of long-term potentiation and spatial learning in mice. In addition, "forward genetics" (from phenotype to gene) with high-efficiency mutagenesis in the mouse can uncover unknown genes and has been used to isolate a behavioral mutant of the circadian system. With the recent availability of high-density genetic maps and physical mapping resources, positional cloning of virtually any mutation is now feasible in the mouse. Together, these approaches permit a molecular analysis of both known and previously unknown genes regulating behavior.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Técnicas Genéticas
/
Genética Comportamental
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article