Further substantiation of a significant role for the sympathetic nervous system in inflammation.
Neuroscience
; 55(4): 1037-43, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8232896
ABSTRACT
This study provides significant new evidence substantiating a role of the postganglionic sympathetic neuron in plasma extravasation in the knee-joint of the rat. Increased plasma extravasation produced by the potent inflammatory mediator bradykinin was mimicked by 6-hydroxydopamine, a selective stimulator of sympathetic fibers. Various treatments (chemical sympathectomy, co-perfusion with the local anesthetic lidocaine, or co-perfusion with depolarizing concentrations of potassium) similarly modulated plasma extravasation induced by both bradykinin and 6-hydroxydopamine, but not that produced by platelet activating factor. We also showed that bradykinin is able to release norepinephrine in the knee-joint, indicating action on the sympathetic postganglionic neuron. In summary, these experiments provide substantial additional evidence supporting a significant contribution of the sympathetic post-ganglionic neuron terminal to inflammatory plasma extravasation.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Simpático
/
Inflamação
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article