Diverse modulation by systemic lidocaine of iontophoretic NMDA and quisqualic acid induced excitations on rat dorsal horn neurons.
Neurosci Lett
; 157(2): 207-10, 1993 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-8233055
ABSTRACT
The effects of systemic lidocaine (3-4 mg/kg) on the responses of 60 wide dynamic range neurons (WDR) to iontophoretically applied N-methyl-D-aspartic acid (NMDA) and quisqualic acid (QUIS) were studied in anesthetized, paralysed rats. The results show that lidocaine induced (i) potentiation of the NMDA excitation, reversible by 7-chloro-kynurenate (7-Cl-KYNA), a selective antagonist of the glycine binding site on the NMDA receptor; (ii) reduction of the QUIS excitation, reversible by strychnine (STRYCH), a glycine antagonist at its receptor. These findings, supporting a glycine-like action of lidocaine, are discussed together with data on the role of excitatory amino acids (EAAs) and the analgesic effect of lidocaine on neuropathic pain.
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Base de dados:
MEDLINE
Assunto principal:
N-Metilaspartato
/
Ácido Quisquálico
/
Glicina
/
Lidocaína
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article