Microsatellite instability in bladder cancer.
Cancer Res
; 53(23): 5620-3, 1993 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-8242615
Somatic instability at microsatellite repeats was detected in 6 of 200 transitional cell carcinomas of the bladder. Instabilities were apparent as changes in (GT)n repeat lengths on human chromosome 9 for four tumors and as alterations in a (CAG)n repeat in the androgen receptor gene on the X chromosome for three tumors. Single locus alterations were detected in three tumors, while three other tumors revealed changes in two or more loci. In one tumor we found microsatellite instability in all five loci analyzed on chromosome 9. The alterations detected were either minor 2-base pair changes or larger (> 2 base pairs) alterations in repeat length. All six tumors were low stage (Ta-T1), suggesting that these alterations can occur early in bladder tumorigenesis.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
DNA de Neoplasias
/
DNA Satélite
/
Carcinoma de Células de Transição
/
Sequências Repetitivas de Ácido Nucleico
Limite:
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article