Cross-reactivity of 75 monoclonal antibodies to human immunoglobulin with sera of non-human primates.
Immunol Lett
; 37(2-3): 207-13, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8258461
ABSTRACT
We systematically analyzed a panel of 75 murine monoclonal antibodies (mAbs) reactive with human immunoglobulins IgG, IgA, IgM, IgD, and kappa and lambda light chains for reactivity with serum immunoglobulins of higher primates. In the great apes, and to a lesser extent in other primates, epitopes related to human light chains, IgM, IgA, IgD, and all 4 IgG subclasses were identified with many of the mAbs. Those mAbs identified as reactive with a given species may be useful for immunologic studies of these species. Cladistic analysis of antigenic relatedness generated a phylogenetic tree consistent with current anatomic or molecular taxonomies.
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Base de dados:
MEDLINE
Assunto principal:
Primatas
/
Imunoglobulinas
/
Anticorpos Monoclonais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article