Protein splicing: excision of intervening sequences at the protein level.
Bioessays
; 15(10): 667-74, 1993 Oct.
Article
em En
| MEDLINE
| ID: mdl-8274142
ABSTRACT
Protein splicing is an extraordinary post-translational reaction that removes an intact central "spacer" domain (Sp) from precursor proteins (N-Sp-C) while splicing together the N- and C-domains of the precursor, via a peptide bond, to produce a new protein (N-C). All of the available data on protein splicing fit a model in which these intervening sequences excise at the protein level via a self-splicing mechanism. Several proteins have recently been discovered that undergo protein splicing, and in two such cases, the excised spacer protein is an endonuclease. Such endonucleases are capable of conferring genetic mobility upon the intervening sequences that encodes them. These intervening sequences define a new family of mobile genetic elements that are translated yet remain phenotypically silent by excising at the protein rather than the RNA level.
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Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Processamento de Proteína Pós-Traducional
/
ATPases Translocadoras de Prótons
/
Proteínas de Saccharomyces cerevisiae
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article