Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines.
J Med Chem
; 37(1): 184-8, 1994 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-8289194
ABSTRACT
This report describes the discovery of a new generation of tetracycline antibacterial agents, the "glycylcyclines". These agents are notable for their activity against a broad spectrum of tetracycline-susceptible and -resistant Gram-negative and Gram-positive aerobic and anaerobic bacteria possessing various classes of tetracycline-resistant determinants [tet B (efflux), tet M (ribosomal protection)]. The design and synthesis of a number of 7-substituted 9-substituted-amido 6-demethyl-6-deoxytetracyclines are described.
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Base de dados:
MEDLINE
Assunto principal:
Tetraciclinas
/
Glicilglicina
/
Antibacterianos
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article