The role of adhesion molecules in the regulation of antibody responses.
Semin Hematol
; 30(4 Suppl 4): 72-9; discussion 80-1, 1993 Oct.
Article
em En
| MEDLINE
| ID: mdl-8303313
ABSTRACT
We used the T-cell-dependent antigen, bacteriophage (phage) phi X174, to study antibody synthesis in patients, guinea pigs, and dogs with complement component deficiencies (C2, C4, C3, C7); in patients with adhesion molecule deficiencies (CD11/CD18 or sialylated Lewisx); and in patients with the hyper IgM (HIM) syndrome (absence of functional gp39 expression by activated T cells). Patients and guinea pigs deficient in early complement components, patients deficient in CD11/CD18, and patients lacking functional gp39 on activated T cells responded to repeated phage immunizations with depressed antibody titers, lack of or inadequate amplification, and failure to switch from IgM to IgG, suggesting that defective T-cell-B-cell interaction is the cause of the antibody deficiency observed in these patients.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Moléculas de Adesão Celular
/
Bacteriófago phi X 174
/
Antígenos Virais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article