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A microwell cytotoxicity assay using Artemia salina (brine shrimp).
Solis, P N; Wright, C W; Anderson, M M; Gupta, M P; Phillipson, J D.
Afiliação
  • Solis PN; Department of Pharmacognosy, School of Pharmacy, University of London, U.K.
Planta Med ; 59(3): 250-2, 1993 Jun.
Article em En | MEDLINE | ID: mdl-8316592
A new microplate assay for cytotoxicity testing using A. salina has been developed and shown to give results comparable to a previously published test-tube method. The assay reliably detected all of the compounds toxic to KB cells in a series of 21 pharmacologically active agents, except for two which require metabolic activation in man. Four quassinoids with cytotoxic and antiplasmodial activity were also toxic to the brine shrimp while quassin itself was inactive in all three systems. It is proposed that this assay provides a convenient means by which the presence of cytotoxic quassinoids may be detected during the fractionation of plant extracts.
Assuntos
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Base de dados: MEDLINE Assunto principal: Artemia / Toxicologia Limite: Animals / Humans Idioma: En Ano de publicação: 1993 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Artemia / Toxicologia Limite: Animals / Humans Idioma: En Ano de publicação: 1993 Tipo de documento: Article