Inverse association between serum total cholesterol and cancer mortality in Dutch civil servants.
Am J Epidemiol
; 137(9): 966-76, 1993 May 01.
Article
em En
| MEDLINE
| ID: mdl-8317454
ABSTRACT
The association between serum total cholesterol and cancer mortality was investigated in a 28-year follow-up study of 3,091 Dutch civil servants aged 40-65 years and their spouses. After adjustment for age, body mass index, and smoking, an inverse association between serum total cholesterol and all-cancer mortality was observed in men during the first 15 years of follow-up, excluding the first 2 years The multivariate rate ratio of those in the lowest cholesterol quintile compared with those in the highest quintile was 2.1 (95% confidence interval (Cl) 1.1-4.0); this association was accounted for mainly by gastrointestinal cancers (RR = 4.2, 95% Cl 1.4-12.9). For follow-up years 16-28, the multivariate rate ratio for all-cancer mortality was 0.8 (95% Cl 0.5-1.40. In women, no consistent association between serum total cholesterol and cancer was observed. After the first 5 years of follow-up were excluded, the significant inverse association in men still persisted. These results suggest that in this study population, low serum cholesterol seems not to be attributable to undetected cancer, but might be a risk factor for cancer mortality in men.
Palavras-chave
Behavior; Biology; Cancer; Causes Of Death; Cholesterol; Demographic Factors; Developed Countries; Differential Mortality; Diseases; Europe; Follow-up Studies; Lipids; Mortality; Neoplasms; Netherlands; Physiology; Population; Population Characteristics; Population Dynamics; Research Methodology; Risk Factors; Sex Factors; Smoking; Studies; Western Europe
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Base de dados:
MEDLINE
Assunto principal:
Colesterol
/
Neoplasias
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
/
Female
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Humans
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Male
/
Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article