The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III.
Mol Cell Biol
; 13(7): 4029-38, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8321210
ABSTRACT
The alpha 2 protein of the yeast Saccharomyces cerevisiae normally represses a set of cell-type-specific genes (the a-specific genes) that are transcribed by RNA polymerase II. In this study, we determined whether alpha 2 can affect transcription by other RNA polymerases. We find that alpha 2 can repress transcription by RNA polymerase I but not by RNA polymerase III. Additional experiments indicate that alpha 2 represses RNA polymerase I transcription through the same pathway that it uses to repress RNA polymerase II transcription. These results implicate conserved components of the transcription machinery as mediators of alpha 2 repression and exclude several alternate models.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
RNA Polimerase I
/
RNA Polimerase II
/
RNA Polimerase III
/
Proteínas Fúngicas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article