Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
Science
; 261(5120): 472-5, 1993 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-8332913
ABSTRACT
Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II. Dexamethasone also induced expression and release of the IL-1R II in PMN. These results, together with the effect of antibodies to IL-1R on IL-1-induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1. The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Interleucina-4
/
Interleucina-1
/
Receptores de Interleucina-1
/
Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article