In vitro evaluation of gallstone dissolution with methyl-tert-butyl ether and ultrasound energy.
Ultrasound Med Biol
; 19(5): 375-83, 1993.
Article
em En
| MEDLINE
| ID: mdl-8356781
Given the large number of cholecystectomies performed annually, a nonsurgical approach to gallstone therapy is of great interest. A laboratory ultrasound system has been developed to study enhancement of methyl-tert-butyl ether (MTBE) dissolution of human gallstones in vitro. A mathematical model that quantitatively characterizes the dissolution process via a rate constant has been developed. Using this model, the kinetics of 15 gallstones from a single patient were evaluated for three dissolution methods: 1) unstirred MTBE, 2) aspirated MTBE, and 3) ultrasonically enhanced MTBE. The results showed excellent fits between the model and measured dissolution rates. 195 kHz continuous-wave (CW) ultrasonically enhanced dissolution rates exhibited a 6.2 fold gain over the manually aspirated MTBE and a 49.5 fold gain over static MTBE dissolution. Investigation of 50% duty cycle pulsed mode ultrasound revealed that total power appears to be the determinant of the observed dissolution rates. Gallstone calcification showed a strong correlation with dissolution rates measured by the model.
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Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Terapia por Ultrassom
/
Colelitíase
/
Éteres
/
Éteres Metílicos
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article