PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation.
J Antibiot (Tokyo)
; 46(7): 1139-44, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8360110
A new macrolide antibiotic, PC-766B, was isolated from the cells of Nocardia brasiliensis SC-4710 by acetone extraction, and purified by gel filtration, silica gel chromatography, HPLC and TLC. The structure of PC-766B was determined by NMR spectral analysis to be a new class of the hygrolidin family antibiotics. PC-766B had a 16-membered macrocyclic lactone ring, a 6-membered hemiketal ring and a 2-deoxy-D-rhamnose moiety. DL-alpha-Tocopherol, known as an antioxidant agent, significantly improved the stability of PC-766B and prevented the decomposition of PC-766B during the storage of the antibiotic.
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Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
/
Antibacterianos
/
Nocardia
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article