Reaction-frequencymetric method: a new analytical technique for determination of submicromolar concentration levels of vitamin C.
J Pharm Sci
; 82(5): 457-60, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8360821
ABSTRACT
A new analytical technique for the assay of pharmaceutical substances at low concentration levels has been proposed and applied to the determination of vitamin C as an example of its application. It is based on the chemical reaction of vitamin C with iodine in a sodium citrate-hydrochloric acid medium, followed by measurement of the frequency change of a silver-plated piezoelectric quartz crystal. The frequency change is proportional to the vitamin C concentration from 2 x 10(-7) to 4 x 10(-6) M. The method was applied to the assay of vitamin C in pharmaceutical preparations.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article