Effects of coencapsulated NGF and GM1 in rats with cortical lesions.
Neuroreport
; 4(7): 971-4, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8369492
Nerve growth factor (NGF) and monosialoganglioside GM1 were microencapsulated in biodegradable co-polymer poly(L-lactide):co-glycolide and administered locally to rats with unilateral cortical devascularizing lesions. Microcapsules were placed directly onto the lesioned cortical surface and rats were sacrificed 30 days post-operatively. Biochemical and quantitative immunocytochemical analyses revealed effective protection from degenerative changes of nucleus basalis magnocellularis (NBM) cholinergic neurones on the lesioned side as well as a significant increase in choline acetyltransferase activity in the frontoparietal cortex surrounding the lesion. Results of this study strongly suggest that the topical application of microcapsules of a biodegradable polymer containing a mixture of two neuroprotective factors is a viable alternative to the use of osmotic minipumps for delivery of these agents into the CNS. Indeed, this approach might find clinical applications.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
/
Córtex Cerebral
/
Ácido Láctico
/
Gangliosídeo G(M1)
/
Fatores de Crescimento Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article