Natural killer cell activity and progression-free survival in ovarian cancer.
Gynecol Obstet Invest
; 35(2): 118-20, 1993.
Article
em En
| MEDLINE
| ID: mdl-8383627
ABSTRACT
A longitudinal evaluation of the natural killer (NK) cell activity of peripheral blood lymphocytes was performed in 17 patients with advanced ovarian cancer (treated surgically and with subsequent multiagent chemotherapy) for a median follow-up period of 32 months. At the time of primary treatment, the mean value of NK cell activity was significantly lower in patients who then had disease progression (p < 0.05) than in patients with progression-free survival. During the follow-up period, no significant modifications of the NK cell activity were observed; only at the time of clinical disease progression did the NK cell activity show a significant reduction. We conclude that the NK cell activity is a potentially important prognostic factor.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Células Matadoras Naturais
/
Adenocarcinoma Mucinoso
/
Cistadenoma
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article