Meningeal carcinomatosis: development of an experimental model.
J Neuropathol Exp Neurol
; 36(2): 228-44, 1977.
Article
em En
| MEDLINE
| ID: mdl-839239
ABSTRACT
An experimental model of meningeal carcinomatosis has been produced by intracisternal inoculation of Walker 256 carcinoma cell suspension into Wistar rats. The tumor grows rapidly and is fatal in about 15 days if 10(6) cells are injected. The histopathological pattern observed is similar to that seen in diffuse leptomeningeal involvement of systemic cancer in human beings. The model will be useful for investigating the pathophysiology of the neurological disability produced by meningeal carcinomatosis and the efficacy of chemotherapeutic agents.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Medula Espinal
/
Neoplasias Encefálicas
/
Carcinoma
/
Modelos Animais de Doenças
/
Meninges
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article