[Importance of portal hypertension in the release of tissue plasminogen activator (t-PA): experimental study in the rat]. / Importancia de la hipertensión portal en la liberación de activador tisular del plasminógeno (t-PA): estudio experimental en la rata.
Rev Esp Enferm Dig
; 84(2): 105-8, 1993 Aug.
Article
em Es
| MEDLINE
| ID: mdl-8398368
ABSTRACT
Tissue plasminogen activator (t-PA) activity was studied in three different experimental models of male Wistar rats; hepatic lesion without portal hypertension, portal hypertension without hepatic lesion and portal hypertension plus function liver suppression by ligation of both portal vein and hepatic artery. t-PA activity was higher in animals with portal hypertension alone than in animals with only hepatic lesion (146%). Maximal values were present in animals with functional liver suppression (1.774% vs. controls, 248% vs. hepatic lesion and 169% vs. portal hypertension only). These results suggest that both reduced hepatic t-PA clearance and portal hypertension could be involved in the increased t-PA activity normally appearing in chronic liver disease.
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Base de dados:
MEDLINE
Assunto principal:
Ativador de Plasminogênio Tecidual
/
Hipertensão Portal
/
Hepatopatias
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
Es
Ano de publicação:
1993
Tipo de documento:
Article