Increased insulin suppression of plasma free fatty acid concentration in exercise-trained rats.
J Appl Physiol (1985)
; 74(1): 293-6, 1993 Jan.
Article
em En
| MEDLINE
| ID: mdl-8444706
ABSTRACT
The effect of exercise training on the insulin suppression of plasma free fatty acid (FFA) concentrations was studied in unanesthetized rats with the hyperinsulinemic-euglycemic clamp technique. Seven rats trained (TR) for 3 h/day by continuous swimming during 8 wk were compared with 6 untrained (UT) body weight-matched rats. Both TR and UT rats were submitted to an exercise swimming session 18 h before the clamp. A smaller mean diameter of adipocytes sampled from the epididymal fat depot was measured in TR animals. The total quantity of glucose infused to maintain euglycemia was 2.2 times higher in TR than in UT animals. No significant differences in plasma insulin concentrations were found between the two groups throughout the experiment. Insulin infusions resulted in a 60% decrease of plasma FFA in TR rats (mean value from 0.46 to 0.18 mM) compared with 27% in UT animals (mean value from 0.45 to 0.33 mM). The data indicate a greater ability of insulin to suppress plasma FFA levels with exercise training, which suggests an increased antilipolytic action of insulin in adipocytes under this condition.
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Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Ácidos Graxos não Esterificados
/
Insulina
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article