Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives.
J Pharm Sci
; 82(3): 286-90, 1993 Mar.
Article
em En
| MEDLINE
| ID: mdl-8450424
ABSTRACT
3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.
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Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Hidrazinas
/
Hidrazonas
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article