Exposure to long wavelength ultraviolet radiation decreases processing of low density lipoprotein by cultured human fibroblasts.
Photochem Photobiol
; 57(2): 302-5, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8451294
ABSTRACT
Exposure of MRC5 human fibroblasts to UVA radiation (365 nm) resulted in a dose-dependent decrease in low density lipoprotein (LDL) uptake and degradation by cells. Following a 25 J/cm2 irradiation dose, about 45% and 70% reduction in 125I-LDL uptake and degradation were observed, respectively. Under the same conditions, the 14C-sucrose uptake was also decreased to about the same extent as LDL uptake. Cell pretreatment with the antioxidants vitamin E and vitamin C did not prevent the UVA-induced fall in LDL degradation. These results point to the possible effects of UVA radiation on receptor-mediated and nonspecific uptake of exogenous molecules. With special regard to the alterations in receptor-mediated processing of exogenous ligands, such a phenomenon could be of importance in UVA-induced skin degenerative processes.
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Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Lipoproteínas LDL
Limite:
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article