Myoglobin protects against endothelial cell membrane damage associated with hydrogen peroxide or xanthine/xanthine oxidase.
FEBS Lett
; 319(1-2): 145-50, 1993 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-8454048
ABSTRACT
Oxymyoglobin at 'physiological' concentrations of 20-100 micromolar protected cultured endothelial cells from damage by xanthine/xanthine oxidase or by hydrogen peroxide. Metmyoglobin also provided a degree of protection, but apomyoglobin was ineffective. Protection was enhanced in the presence of ascorbate (0.01-1 mM). Myoglobin may have a physiological role in the protection of muscular tissue from ischaemia/reperfusion-induced damage.
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Base de dados:
MEDLINE
Assunto principal:
Xantina Oxidase
/
Xantinas
/
Endotélio Vascular
/
Peróxido de Hidrogênio
/
Mioglobina
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article