RBC transfusions in paroxysmal nocturnal hemoglobinuria.
Arch Intern Med
; 137(4): 536-8, 1977 Apr.
Article
em En
| MEDLINE
| ID: mdl-849085
ABSTRACT
Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCS, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.
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Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue
/
Transfusão de Eritrócitos
/
Hemoglobinúria Paroxística
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article