Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.

Kimura, T; Takase, Y; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Yamada, T; Fujimori, T; Saitou, I

Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.

Kimura, T; Takase, Y; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Yamada, T; Fujimori, T; Saitou, I.

Afiliação

Kimura T; Tsukuba Research Laboratories, Eisai Company, Ltd., Ibaraki, Japan.

J Med Chem ; 36(11): 1630-40, 1993 May 28.

Article em En | MEDLINE | ID: mdl-8496930

Assuntos

Anticolesterolemiantes/síntese química; Arteriosclerose/tratamento farmacológico; Compostos de Fenilureia/síntese química; Esterol O-Aciltransferase/antagonistas & inibidores; Animais; Anticolesterolemiantes/farmacologia; Aorta/enzimologia; Técnicas In Vitro; Intestinos/enzimologia; Masculino; Compostos de Fenilureia/farmacologia; Coelhos; Ratos; Ratos Sprague-Dawley; Relação Estrutura-Atividade

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Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Arteriosclerose / Esterol O-Aciltransferase / Anticolesterolemiantes Limite: Animals Idioma: En Ano de publicação: 1993 Tipo de documento: Article

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