Influence of carbamazepine on Li+ ratio in healthy volunteers: an in vitro method.
Clin Neuropharmacol
; 16(3): 216-9, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8504438
Thirty-six healthy volunteers, 19 men and 17 women, were selected to study the possible influence of carbamazepine on Li+ ratio in vitro. The study used within-Ss design. The procedure for preparing and calculating Li+ ratio in vitro followed Pandey's method. Twenty milliliters of blood was withdrawn from each subject, and divided evenly into three test tubes containing sodium heparin. Test tube 1 (control) went through the regular Pandey's method; test tube 2 went through the same procedure, except both the loading and incubation media contained 35 mu mol/L of carbamazepine. The result showed that carbamazepine did not significantly alter Li+ ratio in vitro. The neurotoxicity resulting from lithium-carbamazepine combination might be related to carbamazepine alone or preexisting physical conditions or interactions not related to Li+ ratio.
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Base de dados:
MEDLINE
Assunto principal:
Carbamazepina
/
Lítio
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article