[The physiological characteristics of new agressotropic neuropeptides]. / Fiziologicheskaia kharakteristika novykh agressotropnykh neiropeptidov.

ABSTRACT

Physiological effects of the structural analogs of earlier unknown neuropeptides isolated from the bovine brain were studied. It was shown that intraventricularly and intraperitoneally administered peptides strongly affected different kinds of aggressive behaviour of rats. In addition, the peptides under study influenced various kinds of behaviour presumably linked to formation of the aggressive state of the animal (food and water intake, fear, locomotion). The findings suggest that the peptides modulate dopamine-, serotonin- and glutamatergic neurotransmission which underlie neurochemical mechanisms of aggressive activity.