The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein.
Oncogene
; 11(12): 2699-704, 1995 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-8545128
ABSTRACT
We have previously characterized intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc. Here we present the full-length cDNA sequence of the 6251 bp RLF mRNA. The predicted 1914 amino acid Rlf protein contains sixteen widely spaced zinc finger motifs, and is related to the Zn-15 transcription factor. RLF is widely expressed in fetal and adult tissues, suggesting that it has a general role in transcriptional regulation. The zinc fingers are not contained in the 79 amino acid N-terminal region of RLF involved in the RLF-L-myc fusions, and the transforming ability of the RLF-L-myc and the normal L-myc proteins is indistinguishable. These findings suggest that the role of the rearrangements fusing RLF and L-myc is to deregulate the tightly controlled expression of the L-myc gene.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Rearranjo Gênico
/
Transativadores
/
Genes myc
/
Dedos de Zinco
/
Proteínas de Ligação a DNA
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article