[A new oxa-analog of myristic acid, suppressing replication of the human immunodeficiency virus]. / Novyi oksaanalog miristinovoi kisloty, podavliaiushchii replikatsiiu virusa immunodefitsita cheloveka.

ABSTRACT

A series of oxaanalogs of myristic acid were synthesized and tested for antiviral activity in MT4 cells infected with human immunodeficiency virus 1 (HIV-1). The synthesized acids have no toxic effect on uninfected MT4 cells at a concentration of 100 microM. 14,14,14-Trifluoro-12-oxatetradecanoic acid substantially (by 75%) inhibits the reproduction of HIV-1. Other compounds synthesized, (7Z)-13-, (9Z)-13-, and (7Z)-11-oxatetradecenoic acids, exhibit no antiviral effect.