Effect of physical defenses of the respiratory tract on the development of pneumonia in pigs inoculated endobronchially with Actinobacillus pleuropneumoniae.
J Vet Med Sci
; 57(5): 839-44, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8593289
ABSTRACT
Seven pigs inoculated endobronchially with Actinobacillus pleuropneumoniae (App) serotype 1 developed acute and subacute necrotizing pleuropneumonia. When treated with high doses of atropine (0.25 mg per kg) and/or xylocaine spray using a bronchoscope, which suppressed mucus secretion and ciliary activity, the pigs showed severe pleuropneumonia and 2 treated pigs died within 36 hr after inoculating 320 colony forming units (CFU)/2ml of App serotype 1. Histopathologically, their lungs had alveolar and interlobular edema and intravascular fibrinous thrombosis. In the surviving pigs, the lymph nodes had App antigens in the germinal centers corresponding closely with activated follicular dendritic cells and increased in the number of IgG- and IgM-containing cells. The bacterial antigens were also observed as small sized granules in the cytoplasm of bronchoalveolar macrophages. These findings suggest that the attachment of App to the mucosal surface may be crucial in the development of pneumonic lesions.
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Base de dados:
MEDLINE
Assunto principal:
Doenças dos Suínos
/
Infecções por Actinobacillus
/
Actinobacillus pleuropneumoniae
/
Pneumonia Bacteriana
/
Pulmão
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article