Eukaryotic gene expression: metabolite control by amino acids.
Prog Nucleic Acid Res Mol Biol
; 53: 219-48, 1996.
Article
em En
| MEDLINE
| ID: mdl-8650304
ABSTRACT
Our understanding of the metabolite control in mammalian cells lags far behind that in prokaryotes. This is particularly true for amino-acid-dependent gene expression. Few proteins have been identified for which synthesis is selectively regulated by amino-acid availability, and the mechanisms for control of transcription and translation in response to changes in amino-acid availability have not yet been elucidated. The intimate relationship between amino-acid supply and the fundamental cellular process of protein synthesis makes amino-acid-dependent control of gene expression particularly important. Future studies should provide important insight into amino-acid and other nutrient signaling pathways, and their impact on cellular growth and metabolism.
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Regulação da Expressão Gênica
/
Fungos
/
Aminoácidos
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article