Treatment of human immunodeficiency virus infection with hydroxyurea: virologic and clinical evaluation.
J Infect Dis
; 174(1): 204-9, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-8655996
ABSTRACT
To assess the efficacy of the therapeutic use of inhibitors of ribonucleotide reductase for the treatment of human immunodeficiency virus (HIV) type 1 infection, 7 consecutive patients were enrolled in a clinical trial involving monotherapy with hydroxyurea for 8-19 weeks. During therapy, patients were evaluated for clinical status and immunologic, hematologic, and quantitative virologic parameters, including determinations of viremia and the number of provirus-containing cells by competitive polymerase chain reaction. In all patients, these parameters were not modified during the course of therapy. The number of CD4 cells remained generally unchanged or showed a tendency to further decline. No sign of improvement in HIV disease was detected in any patient. These observations indicate that monotherapy with hydroxyurea does not provide therapeutic benefit to HIV-1-infected patients.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Síndrome da Imunodeficiência Adquirida
/
Inibidores Enzimáticos
/
Hidroxiureia
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article